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2014TX01R145), the Natural Science Foundation of Guangdong Province (2017A030312003, 2018A0303131004), the Natural Science Foundation of Guangdong Province for Distinguished Young Scholars (2018B030306001), the Sci-Tech Project Foundation of Guangdong Province (2014A020212103), the Health & Medical Collaborative Innovation Project of Guangzhou City (201400000001, 201803040003), Pearl River S&T Nova Program of Guangzhou (201806010135), the Planned Science and Technology Project of Guangdong Province (2019B020230002), the National Science & Technology Pillar Program during the Twelfth Five-year Plan Period (2014BAI09B10), Natural Science Foundation of Guangdong Province (2017A030312003), and the Fundamental Research Funds for the Central Universities