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Warning signs include persistent fatigue despite adequate sleep, cold intolerance (especially cold hands and feet), menstrual irregularity or cessation in female subjects, hair thinning or shedding, and mood disturbances (irritability, low motivation)
Symptoms like dizziness, confusion, and weakness may occur, and long term use could contribute to insulin resistance, increasing the risk of metabolic disorders
Pharmacological Reports , 2018 Anti-Inflammatory Effects It reduces levels of pro-inflammatory cytokines like TNF- and IL-6 while modulating nitric oxide (NO) pathways that contribute to gut permeability and motility issues
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