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PPAR- activation is translated into different vascular and metabolic effects including the upregulation and downregulation of different genes essential for e lipid and glucose metabolism, but also for inflammatory response

However, the interesting part of this study mentioned how as the animals aged there was no clear reduction in longevity despite the obesity that developed, but when these animals were placed on a low-fat diet, lifespan increased by 30%

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That constraint is part of why the compounded GLP-1 landscape changed after the FDA resolved the semaglutide and tirzepatide shortages in 2025