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The peptide's therapeutic mechanism depends on binding to NNMT before dietary nicotinamide floods the system

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Acute skin anemia: a type of anemia caused by a sudden decrease in the production of blood cells

However, FOXO4-DRI treatment significantly reduced the expression of these detrimental SASP factors and, critically, restored the proliferation of GC-1 spg cells in the co-culture system, as evidenced by CCK-8 assays and PCNA expression, without inducing apoptosis in the spermatogonia