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Our findings describe a role for mitochondrial plasticity as a mechanism for acute 5FU tolerance in CRC cells: mitochondrial changes acutely adopted by CRC cells in response to 5FU-based standard-of-care treatment result in increased mitochondrial biogenesis, which provides metabolic support for increased pyrimidine scavenging by UCK2 to resolve nucleotide stress

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POTS is one specific form of dysautonomia characterized by an abnormal increase in heart rate upon standing, accompanied by symptoms of orthostatic intolerance

[PMID: 42278509] PubMed record related to this compound for laboratory literature review