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4 Discussion As the global population continues to age, the urgency to develop effective therapeutic strategies against AD has never been more critical

Collectively, these molecular and cellular changes highlight the complex interplay of genetic, oxidative, metabolic, and inflammatory pathways that underlie the neurodevelopmental impairments in DS

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3 4 12 17 29 33 However, the mechanisms underlying the relationship between elevated plasma free radical concentration and poor insulin-mediated glucose uptake are still unclear, 2 8 9 10 and whether oxidative stress precedes or follows hyperinsulinemia/insulin resistance is still an open question