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Exenatide may still serve a role in cost-constrained settings or when newer agents are unavailable, but semaglutide is the clear standard of care for new GLP-1 agonist prescriptions

Ideal candidates should be committed to making lasting lifestyle changes, including a healthy diet and regular physical activity

Tirzepatide is a dual GLP-1 and GIP receptor agonist, meaning it acts on two hormone pathways rather than one