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Pickart's foundational work and subsequent studies on copper peptides and wound closure point to upregulation of matrix metalloproteinases, the enzymes responsible for remodeling collagen into organized structure during repair, rather than the disorganized collagen deposition that produces visible scarring

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First, the -methyl-phenylalanine substitution at position 2 confers complete resistance to DPP-IV cleavage, the enzymatic step that inactivates native incretins within minutes