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Semaglutide is not currently licensed for use in children under the age of 12, and safety evidence for its use in high-risk geriatric groups is limited [16]
PMID: 41 KaiharaKADicksonLMEllenbroekJHOrrCMDLaydenBTWicksteedB
However, despite the rather modest weight loss with the drug in this trial, these patients with preserved ejection fraction heart failure demonstrated clinically significant improvements in quality of life, measures of functional capacity, reductions in important biomarkers including NT proBNP and CRP, and numerically less likelihood of heart failure decompensation. In the published paper, the researchers hypothesize that the weight-loss-independent benefits of semaglutide in HFpEF may include direct effects on decongestion
Retatrutide targets three receptors GLP-1, GIP, and glucagon which is why clinics and influencers slapped the name GLP-3 on it
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