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Phase 3 data showed lower rates of nausea and vomiting compared to GLP-1 therapiespotentially better tolerated for some patients
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(2020) reported that increased levels of proinflammatory cytokines (IL-1 and IL-18) and ASC were detected in serum samples from patients with severe AP
This not only reduces cellular ATP by a great amount, but the resulting tissues acidity may contribute to pain hypersensitivity through sensitizing peripheral pain receptors
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