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Oral supplementation is usually sufficient for individuals with mild to moderate deficiency due to dietary insufficiency or malabsorption disorders

Dose escalation typically occurred every four weeks to minimize gastrointestinal adverse effects, mirroring the titration approach used for Semaglutide and Tirzepatide

The appetite suppression pathway (GLP-1): Retatrutide crosses the blood-brain barrier and acts on hypothalamic neurons that regulate hunger and satiety

Weeks 1 to 4: 20 units (0.2 mL) once weekly Weeks 5 to 8: 40 units (0.4 mL) once weekly Weeks 9 to 12: 70 units (0.7 mL) once weekly Weeks 13 to 16: 90 units (0.9 mL) once weekly These are unit measurements based on insulin syringe markings