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Lorcaserin is a 5-HT2CR agonist approved for weight management, but it was withdrawn in 2020 due to a numerical imbalance in the cancers occurring in an over 12,000-participant clinical trial (118)

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doi: 10.1038/s41591-025-04106-7

These milestones highlight the growing regulatory and clinical momentum supporting expanded uses Ongoing trials are also exploring the impact of GLP-1 agonists on cardiovascular outcomes, liver health, and even neurodegenerative diseases, reinforcing their value in treating systemic metabolic disorders