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As the transport of substrates and drugs by MRP1 relies on unclear relationships with GSH binding and transport 9,10 , we looked at the ability of the different chimeras to confer a MDR phenotype in a GSH-dependent manner
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The etiopathogenesis of DM is not fully elucidated, but it is suggested that genetic and environmental factors are involved in this metabolic disorder and, in this sense, oxidative stress becomes one of the important pathways for this understanding [3]
The other rewires your metabolism from multiple angles at once
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