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Interestingly, after comparing the KEGG pathways identified above, we found 10 pathways regulated by both T3 administration and nutrition ingestion, which also include the primary BA synthetic pathway (Fig

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[16] [18] These metabolites, including cyclic 3-hydroxymelatonin, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), and N1-acetyl-5-methoxykynuramine (AMK), contribute to the broader antioxidative effects of melatonin through further redox reactions with free radicals