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NNMT acts as a primary metabolic gatekeeper, predominantly active in fat tissue and liver cells, where it methylates nicotinamide (NAM) using S-adenosyl-L-methionine (SAM) as a methyl donor
TB-4 is on the prohibited list
Vitamin B12 deficiency causes fatigue and other ME/CFS-like symptoms so it should be excluded before a diagnosis of ME/CFS is made, especially in people where there is no clear infective onset
While it seems intuitive to massage the area, rubbing can increase bruising and irritation
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