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[2] [11] [12] [13] [15] CNS stimulation (consisting of nervousness, anxiety, agitation, tremor, spasticity, euphoria, emotional lability, and hallucinations) has been reported in 7% of patients receiving immediate-release tramadol at 7 days and 14% at 90 days of treatment

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34 The AMPLITUDE-O trial demonstrated significant dose-dependent effects of efpeglenatide on HF hospitalisation in patients with T2D and CVD or renal disease, along with one risk factor