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Decades of preclinical and limited clinical research suggest that DSIP may enhance slow-wave sleep, support neuroendocrine function, and offer protective effects in certain physiological contexts, including post-stroke recovery and age-related cellular stress
S Afr J Bot 142:106113
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Consistent with these findings, previous in vitro studies showed that OXM is a full agonist at the GCGR and GLP-1R but is 3-fold less potent at the GCGR than native glucagon and 100-fold less potent at the GLP-1R than native GLP-1, in terms of activating cAMP accumulation ( Despite convincing data suggesting the central role of GLP-1R signalling in the food intake reduction effects of OXM, there were still some unexplained effects of the gut hormone including increased energy expenditure, suggesting a GLP-1R independent mechanism of action (35)
