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En la membrana interna de la mitocondria, la colina oxidasa dependiente de dinucletido de flavina adenina (FAD) cataliza la conversin de colina en betana aldehdo, que luego es convertida en betana por la betana aldehdo deshidrogenasa en la matriz mitocondrial o en el citosol (2)
Proinflammatory cytokines TNF- and IL1- activate the canonical NF-B pathway that induce the gene expression of cyclooxigenase-2, inducible nitric oxide synthase-3, inflammatory cytokines, and matrix metalloproteinases [75] These changes lead to the damage of TJs, decreased endothelial integrity and increased permeability at the BBB [73, 76], and to neuroinflammation and the development of chronic neurodegenerative diseases such as AD [10, 77]
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