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How Tirzepatide Works Tirzepatide's dual agonism creates synergistic metabolic effects: GIP receptor activation enhances insulin secretion and may improve fat metabolism GLP-1 receptor activation suppresses glucagon, slows gastric emptying, and reduces appetite Combined pathway stimulation produces greater metabolic benefits than single-pathway agonists Dose-dependent effects allow for personalized titration based on individual response The dual mechanism explains why tirzepatide has demonstrated superior weight loss outcomes compared to single GLP-1 agonists in head-to-head clinical trials

Barnett C, Costill DL, Vukovich MD, Cole KJ, Goodpaster BH, Trappe SW, et al

NEJM , 359(7):715-721.

9b), ETC complex expression (CIII, CI