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Key Takeaways Semaglutide can induce rapid weight loss which typically results in subcutaneous fat loss and accelerated collagen loss, putting patients at risk for loose skin, facial hollowing and deeper wrinkles

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In the SUSTAIN clinical trial program for type 2 diabetes, nausea was reported in approximately 15-20% of participants, while vomiting occurred in roughly 5-9% of patients receiving semaglutide, compared to lower rates in placebo groups