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Furthermore, some studies on the relationship between TMAO levels and CVDs identified kidney function as an important confounder, owing to a degree of decline in the renal function of patients with CVDs (140)

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In the initial stages of research into the heterogeneity of astrocyte responses, two distinct types of reactive astrocytes were identified: inflammatory/neurotoxic astrocytes, referred to as A1 astrocytes, and neuroprotective astrocytes, referred to as A2 astrocytes ( Astrocytes have been found to increase the expression of transmembrane receptors for IL-17 and TrkB in response to neuroinflammation