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It has been discussed before, thatdue to the differential influence of enzymes and competing reactions in complex cellular systems 4,57 the midpoint redox potential of GRXs determined in vitro does not necessarily allow predictions on their redox states in vivo

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Shin TK, Kang MS, Lee HY, Seo MS, Kim SG, Kim CD, Lee WS (2009) Fluoxetine and sertraline attenuate postischemic brain injury in mice

Its selective ghrelin receptor targeting and minimal side-effect profile make it valuable for studying growth hormone axis function independently