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The STEP trials represent some of the largest and most rigorous weight loss intervention trials ever conducted, with outcomes that exceed what bariatric surgery achieved in trials a decade ago
According to Reuters, the weight loss data compares favourably with semaglutide (sold as Ozempic), with trials for that injectable treatment showing patients living with diabetes lost around 6% of their body weight on the highest dose
It activates NPY-related neurons in the PVN through the PKC-Ca2+-CaMKK2-AMPK signaling pathway, thereby promoting appetite [36, 39]
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