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Two clinical signatures follow: a measurable rise in resting energy expenditure (REE) independent of caloric deficit, and substantial reductions in intrahepatic lipid

People with diabetes are already at increased risk of the condition, which is one reason these findings call for careful interpretation rather than a headline-driven reaction

Understanding why this occurs and implementing targeted nutritional and hydration strategies can help patients maintain energy levels while benefiting from treatment

These label expansions unlocked new pathways for coverage, and by early 2025 the proportion of Medicare patients with diabetes or obesity initiating GLP-1 therapy rose sharply