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While more human trials are needed to further explore this topic, one study showed depleted levels of glutathione in the hippocampus of generally healthy elderly persons, resulting in mild cognitive impairment, a precursor to more advanced impairment down the road

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Symptoms of excessive intake appear at 5,0009,000 mg per day, an amount significantly higher than typical supplementation

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Many researchers notice effects within 24 weeks of daily use

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