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While this class of drugs was initially approved for type 2 diabetes, it has recently gained global attention for cardiovascular risk reduction and weight loss in patients with obesity, irrespective of the presence of diabetes

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Remaining on lower doses substantially reduces weight loss efficacy

Protein samples (20 g) were separated on NuPage Novex 4%12% Bis-Tris gels (Life Technologies, Carlsbad, CA, USA), then transferred to PVDF membranes (Rockford, IL, USA), which were blocked with non-fat milk and incubated with primary antibodies (OXPHOS complexes