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Phase 2 dose-finding trial Published in The Lancet in 2021, this multicenter, randomized, double-blind trial tested cagrilintide doses ranging from 0.3 mg to 4.5 mg weekly in people with overweight or obesity

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However, Epithalon remains investigational with no FDA approval, most research conducted in Russia with limited Western replication, long-term human safety data sparse, optimal dosing protocols still debated, and mechanisms not fully understood

Blood concentration of glucose, haematocrit level, pulse rate and blood pressure are measured at 30-min intervals for up to 3 h after the ingestion