30 , 14251432 (2011) Lazarevic, V
The therapeutic use of peptides dates back over a century
These include homomeric GluK1 bound to agonist Glu (Selvakumar et al., 2021), homomeric GluK2 bound to the positive allosteric modulator (PAM) BPAM344 (BPAM) (Gangwar et al., 2023b), negative allosteric modulator (NAM) perampanel (PMP) (Gangwar et al., 2023b), and ion channel blockers (Gangwar et al., 2024a), homomeric GluK2 in complex with Neto2 bound to the agonist kainic acid (KA) and competitive antagonist 6,7-dinitroquinoxaline-2,3-dione (DNQX) (He et al., 2021), heteromeric GluK2/GluK5 bound to agonist Glu and competitive antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) (Khanra et al., 2021), and homomeric GluK3 bound to the agonist SYM 2081 and competitive antagonists UBP301 and UBP310 (Kumari et al., 2019
With the help of an enzyme called glutathione peroxidase, glutathione inactivates the superoxide, free radicals, hydrogen peroxide, lipid peroxides, and peroxinitrites that cause this "lipid oxidation" and wreak havoc on your health
