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Additionally, the cost burden on healthcare systems may prompt scrutiny from regulators and policymakers, potentially leading to price negotiations or caps that could affect market profitability

Lipopolysaccharide-induced increase of prostaglandin E(2) is mediated by inducible nitric oxide synthase activation of the constitutive cyclooxygenase and induction of membrane-associated prostaglandin E synthase

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While public interest has amplified their profile, clinical trial evidence supporting glycemic, weight, blood pressure, and cardiovascular benefits has helped drive adoption