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Khound R, Taher J, Baker C, Adeli K, Su Q

Safety in TRIUMPH-1 The safety profile was consistent with incretin-class therapies: Most common AEs (12 mg dose): - Nausea: 42.4% - Diarrhea: 32.0% - Constipation: 26.1% - Vomiting: 25.3% Dysesthesia (a sensory disturbance tingling, numbness) and urinary tract infections were reported in approximately 10% of patients on the highest doses, but were generally mild to moderate and mostly resolved during treatment

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This dual effect on both sides of the energy balance equation is why retatrutide produced the highest weight loss percentages of any single-agent trial