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"BUILD-3: a randomized, controlled trial of bosentan in idiopathic pulmonary fibrosis"

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Activation of the Glucagon receptor promotes thermogenesis (heat production) and lipolysis (fat breakdown)

Zhu et al

The greater decrease in LAC levels in severe forms of MDD and in patients with treatment resistant depression (TRD) is akin to a kindling-like progression of depression in that earlier age at onset and/or the presence of early life adversity, such as emotional trauma, conveys liability to more severe and treatment-resistant course of illness [51, 53, 55]