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CACT acetylation compromises its activity, causing a decrease in its transport function

In addition, dysregulated mitochondrial biogenesis and excessive ATP release under oxidative conditions act as damage-associated molecular patterns (DAMPs), activating inflammasomes and enhancing chemotactic signals for immune cells like CD8 + T cells 67

Limited long-term safety data

Due to the low incidence rate of Von Hippel-Lindau syndrome in the population, clinical studies on VHL have been limited to animal studies and retrospective case-control studies, and cohort studies are still needed to further validate the mechanisms involved