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2.5.2 The Keap1-NRF2 pathway mediates ferroptosis The NRF2 transcription factor stimulates the production of NADPH by blocking the expression of antioxidant genes and increasing the expression of enzymes in the pentose phosphate pathway, which decreases the sensitivity of cells to ferroptosis (85)

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Local hormone concentrations in follicular fluid often correlate more strongly with oocyte competence and IVF outcomes than systemic endocrine measures, supporting the view that the follicular unit constitutes a partially autonomous endocrine microenvironment [206, 250, 251]