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Their mode of action is inclusive of increasing release of insulin in a glucose-dependent manner, thereby lowering the risk of hypoglycemia as compared to the other anti-diabetic agents
Citation28 NPs have special features like high ratio of surface to volume, nanometers size, and deep tissue penetration which effect enhanced permeability and retention
GLP-1s increased the release of insulin but had an extremely short half-life (one to two minutes), making them highly unfavorable as a treatment for diabetes
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