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Rapid weight loss under GLP-1RA therapy may compromise lean mass and is frequently followed by weight regain upon treatment discontinuation

In individuals with Type 2 Diabetes (T2D), there is an observed increase in Gram-negative Enterobacteriaceae and a concurrent decrease in acetic acid-producing bacteria, such as Bifidobacteria

The LIVE trial, conducted in stable HFrEF patients (with or without T2D), found no significant effect of liraglutide on the change in LVEF with increased arrhythmic events