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When titrating SmTrx to the U597C enzyme we observe a slowing in rate of the first reoxidation event, which approaches the rate of turnover of the enzyme with Trx as the oxidant (from 2 s 1 to 0.12 s 1 ), and a complete loss of the second slower reoxidation event
Many of the most common side effects (headaches, water retention) respond well to increased water intake, especially during the first few weeks
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