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In a 5-day phase 1 MAD trial where four groups of healthy volunteers received twice-daily or thrice-daily doses of GLY-200, decreases in glucose and insulin, along with increases in bile acids, GLP-1, peptide YY, and glicentin are noted in the cohorts with twice-daily dosing versus those receiving placebo (150)

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We performed fecal microbiota transplantation to germ-free mice with feces from donors of two high-TMAO producers and two low-TMAO producers based on pre-supplement OCCT results (Figure S9a)