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Inhibitors do not convert TGR into an NADPH oxidase Several covalent inhibitors of TGR are electrophilic compounds reacting with the Sec residue at the C-terminus, which induce a transition in the enzyme from an antioxidant to a pro-oxidant with increased NADPH consumption 20,45

In December 2021, The New England Journal of Medicine published data that showed a three-day course of remdesivir significantly reduced the risk of hospitalization in people with COVID-19 at high risk for disease progression