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Four days after the experiment, it was reported by the researchers that the murine models presented with TB-500 showed an apparent 41% increment in the re-epithelialization process (i.e., formation of new epithelial cells to resurface the wound)

Lake, B

Taken together, the pattern suggests that a controlled, short-lived immune activation may accompany epithelial repair, consistent with the accelerated wound closure observed in HCEpiC assays under basal, inflammatory and oxidative stress conditions ( Importantly, the interpretation of increased Th1-associated cytokines as part of a repair-associated response rather than purely deleterious inflammation is supported by emerging evidence on corneal wound healing biology ( It is also worth mentioning that cellular redox homeostasis could influence cellular pathways influencing cell fate and differentiation ( Among the strengths of the present study, the prospective, double-blind, two-period crossover design enabled within-subject assessment of clinical outcomes and tear-fluid cytokines, minimizing inter-individual variability and improving efficiency to detect reversible changes