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Although the regulatory bodies did not confirm these performance-enhancing effects, the use of TB-500 was quickly prohibited in the sport [12, 13]

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CYP2D6 exhibits a marked genetic polymorphismover 70 alleles (www.cypalleles.ki.se/cyp2d6.htm) have been described whose combination leads to four phenotypes: poor, intermediate, extensive, and ultrarapid metabolizers (PM, IM, EM, and UM, respectively)