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Rapid weight loss may increase the risk of muscle loss, fatigue, gallstones, hair thinning, and loose skin
The distinct contributions of each receptor system - GLP-1-mediated improvements in insulin sensitivity and appetite regulation, GIP-mediated enhancement of insulin secretion and adipose tissue function, and glucagon-mediated direct hepatic metabolic modulation and increased energy expenditure - create synergistic benefits when engaged through dual or triple agonist formulations
Because these medications act on underlying appetite regulation pathways rather than delivering a one-off fix, in this article's framing
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