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In essence, the blood-brain barrier plays a pivotal role in maintaining the internal environment of the brain, making it one of the most significant protective mechanisms in the human body

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In rare cases, improper technique or contamination can lead to a sterile abscess, tissue necrosis, or phlebitis (inflamed vein)

The robust presence of innate immune elements at the leading edges led some to conclude that in these chronic active MS lesions, there is a switch with the innate rather than the adaptive immune system taking over to propagate the pathology (Weiner, 2008)