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It works by blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby reducing blood pressure, decreasing the workload on the heart, and reducing aldosterone secretion

While the medications themselves remain undetectable in routine laboratory work, their therapeutic effectsincluding improved hemoglobin A1c, fasting glucose, and lipid profilesare clearly measurable

This shift directly affects pharmaceutical marketing