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After uptake by cancer cells, Pt (IV) prodrugs are reduced by intracellular GSH to produce active Pt (II) complexes, leading to the exhaustion of GSH
Eur J Clin Chem Clin Biochem 35 : 687691
High levels of MAO-A were found in mitral valve regurgitation, and the MAOs were shown to contribute to the oxidative stress in the heart valve.[ref] These cardiovascular effects highlight that MAO-A is not only a brain enzyme but also a significant source of oxidative stress in the heart and veins
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