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Systolic blood pressure declined by 9.9 mm Hg with the combination and 3.2 mm Hg with placebo (-6.7 mm Hg difference
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There, Novo Nordisk could not keep up with the staggering demand and there were frequent shortages throughout 2022 and into early 2025
By the late 1980s, it was clear that therapeutically using GLP-1 would require either modifying the molecule to last longer or finding another way to keep levels high
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