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The Role of Leydig Cells Leydig cells are the "factories" of the male hormonal system
Their highly conserved regulatory, kinase, and association domains make isoform selectivity a key challenge, as each has distinct tissue-specific functions, and off-target inhibition may cause toxicity
IGF-1 Des (des(13) IGF-1) is N-Terminally truncated synthetic analog of insulin-like growth factor-1 with deletion of the first three amino acids endowed with lower affinity for insulin-like growth factor binding proteins (IGFBPs) and different interaction kinetics with the receptor
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