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Importantly, as shown in the first row, LASSS supplementation effectively prevented an increase in the nitration level of ECM-HGF, whereas GSSSG did not demonstrate efficacy, inconsistent with its potent potential shown in in vitro experiments described earlier (see Figure 1b)

The literature is conflicting on this topic, and although in vitro studies in obese mice have shown a positive effect of semaglutide in promoting muscle protein synthesis, increasing the relative proportion of skeletal muscle, and improving muscle function [119, 120], a synergistic dietary strategy such as the MD may help mitigate this concern and optimise the quality of weight loss