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The biggest factor is the immune system, how intact it is as we age, and inflammation

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Transforming growth factor-1 (TGF-1) can induce the EMT phenotype in melanoma cells and upregulate the levels of GPX4 and SLC7A11, while gambogenic acid, a xanthone derived from traditional Chinese medicine Gamboge, can promote ferroptosis by inhibiting the SLC7A11/GPX4 pathway in melanoma cells stimulated by TGF-1

Individual results vary, and the drug is still under investigation, but these outcomes are considered groundbreaking in obesity medicine