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Many treatments approved for T2DM treatment such as sulphonylureas and thiazolidinediones (TZDs) improve glucose metabolism but have the unwanted side effect of causing weight gain (Thule and Umpierrez, 2014) and (Kahn et al., 2006

Abrupt discontinuation produces the worst outcomes in every study that has examined it

In one study of nearly 38,000 elderly men who were dementia-free at the beginning of the study, those with hearing loss had a 69% higher risk of developing dementia during an average of 11.1 years of follow-up

These symptoms are thought to result from slowed gastric emptying and altered gut motility