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108 It forms two distinct complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), with mTORC1 being the primary regulator of autophagy
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Similar effects have been demonstrated in osteoarthritis models, where liraglutide facilitates macrophage polarization toward the anti-inflammatory M2 phenotype by downregulating M1-associated markers such as Mcp-1 and Cd38, while upregulating M2-related genes including Erg-2, reducing the secretion of pro-inflammatory cytokines and mitigates inflammatory responses (Meurot et al., 2022)
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